Used 2021 Mercedes-Benz E-Class for SaleNationwide

How much does the 2021 Mercedes-Benz E-Class cost?

Prices have softened 12.15% compared to this time last year, making it a favourable time to shop this model year.

There are 75 listings available, which suggests a modest amount of inventory for you to compare.

Is the 2021 Mercedes-Benz E-Class a good car?

Yes — the 2021 Mercedes-Benz E-Class earns a 4.7/5 user rating and an 8.33/10 expert rating. The model scores 10/10 across Technology and Safety.

Owners consistently praise the luxury feel, the powerful engine choices, and the comfortable interior. The design also stands out, and the advanced features help it feel especially well equipped for a midsize luxury car. In practical terms, it suits you if you want a car that can be tailored toward comfort, performance, or a more expressive personality depending on configuration.

There are 38.7% good or great deals in the market, which gives you some room to find a strong example.

Is the 2021 Mercedes-Benz E-Class reliable?

Owners rate it 4.7/5, a strong signal of long-term satisfaction.

The owner feedback points to a dependable ownership experience, with praise for the car’s luxury, performance, and comfortable interior. The expert assessment also describes it as a quiet and excellent choice for a car this size, which supports the sense that it is built to be easy to live with over time. Mercedes also positions the E-Class as a practical and versatile car, which reinforces its long-term usability.

For used buyers, the main ownership risk is cost: this is a complex luxury car, so you should be prepared for higher repair and maintenance exposure than with a mainstream model.

What should I look for when buying a used 2021 Mercedes-Benz E-Class?

Key things to evaluate:

• Trim level: The cabin is rich even in baser trims, but the Luxury package formerly brought smaller wheels and a softer-riding, slightly taller suspension, while the Sport style is more popular and the AMG models add vertical grille slats and quad exhaust tips.
• Powertrain: The E350 uses a 2.0-litre turbo four-cylinder that is described as underwhelming, while the E450’s 3.0-litre electrified inline-six is quiet and excellent; the AMG E53 adds more boost and stronger performance, and the E63 S is the extreme V8 model.
• Safety package: Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. All other driver-assist features are optional, so you should check carefully for the equipment you want.
• Infotainment: The system uses MBUX with touch, swipe, and voice control, plus two 12-inch screens and a standard digital instrument panel. Apple CarPlay and Android Auto are standard, but they are not wireless, and the system does not update over-the-air.
• Fuel efficiency: The E450 4Matic sedan returns 9.2 L/100 km combined, the E350 4Matic sedan returns 9.4 L/100 km combined, the AMG E53 sedan returns 9.5 L/100 km combined, and the AMG E63 sedan returns 12.8 L/100 km combined.

Which 2021 Mercedes-Benz E-Class trim should I buy?

The 2021 Mercedes-Benz E-Class is offered in 13 trim levels: E350, E350 4Matic, E450 4Matic, AMG E53, AMG E63 S, and the coupe, cabriolet, and wagon body-style variants explicitly referenced in the source material.

Here's the short version:

• E350: This is the least expensive path into the lineup, but the 2.0-litre turbo four-cylinder is described as underwhelming, so it makes sense mainly if you want the badge and luxury ambience more than strong acceleration.
• E350 4Matic: Choose this if you want the same entry-level approach with all-wheel drive and a bit more confidence in Canadian weather.
• E450 4Matic: This is the best-value choice for most shoppers because the electrified 3.0-litre inline-six is described as quiet and excellent, and it delivers the strongest balance of refinement and performance.
• AMG E53: Pick this if you want a more performance-focused E-Class with brisk acceleration, rear-biased AWD, and variable-rate air suspension, while still keeping everyday comfort.
• AMG E63 S: This is the one for you if you want the most extreme performance in the range, with the hand-built V8, lowered and widened chassis, and track-ready character.

The 2020 E-Class sedan earned a Top Safety Pick+ rating from IIHS, and the 2021 sedan and wagon include standard safety equipment plus a broad list of optional driver-assist features.

Is now a good time to buy a used 2021 Mercedes-Benz E-Class?

This is a moderate market for selective buyers, so you have enough choice to shop carefully without feeling rushed.

• Deal availability: 38.7% of listings are priced as good or great deals.
• Inventory: There are 75 listings available.
• Price trend: Prices have softened 12.15% compared with last year.

If you find a listing below $62,928 CAD, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Mercedes-Benz E-Class's resale value?

The current average of $66,489 CAD sits slightly below last year's $75,680 CAD.

That decline suggests future sellers may need to price more competitively than owners did a year ago. It also means depreciation has already done some of the work for you if you are buying now, which can help support stronger value retention from this point forward. Because the market has softened, a well-kept example with desirable equipment should stand out more clearly to future shoppers.

Vehicles with strong owner satisfaction ratings, like this model year's 4.7/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Mercedes-Benz E-Class safe?

The 2021 E-Class sedan and wagon earn five-star overall ratings from NHTSA, with five-star ratings in frontal and side crash tests and for rollover vulnerability, though the driver's side received a four-star rating in the frontal crash test. The 2020 E-Class sedan was rated a Top Safety Pick+ by IIHS.

It earns a 10/10 safety score from our experts.

Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. Other driver-assistance features are optional, and there are 14 of them in total. The model also includes Pre-Safe Sound, side-bolster inflation in a side collision, and steering and brake intervention for crosswinds.

Should I buy a 2021 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 38.7% of listings are priced as good or great deals.
• Price trend: Prices have softened 12.15% compared with last year.
• Owners rate it 4.7/5 — a strong satisfaction signal.
• It gets a mid-cycle update to the infotainment system, engines, and exterior styling.

Consider the 2022 if:

• At $54,163 CAD, the 2022 costs less than the current year's $66,489 CAD average.
• It changes very little after the 2021 refresh.

The bottom line: The 2021 is the better pick if you want the refreshed version with broader appeal and strong market support. If your priority is spending less and you are comfortable with minimal year-over-year change, the 2022 is the more price-sensitive alternative.

These recommendations are based on CarGurus' proprietary market data from September 22, 2026, CarGurus experts' opinions, and generative AI.