Used 2021 Mercedes-Benz E-Class for SaleNationwide

How much does the 2021 Mercedes-Benz E-Class cost?

Prices have softened 21.96% compared to this time last year, making it a favourable time to shop this model year.

There are 83 listings available, which gives you a solid amount of inventory to compare.

Is the 2021 Mercedes-Benz E-Class a good car?

Yes — the 2021 Mercedes-Benz E-Class earns a 4.7/5 user rating and an 8.3/10 expert rating. The model scores 10/10 across Technology and Safety.

Owners consistently praise its blend of luxury, performance, and beautiful design, along with the comfortable interior and advanced features. It also stands out for its versatility, with the kind of breadth that lets you tailor it toward comfort, performance, or a more feature-rich luxury experience.

For you, that means the E-Class makes the most sense if you want a midsize luxury car that can be configured in very different ways without losing its upscale character. 36.1% of listings are priced as good or great deals, which suggests there are worthwhile opportunities in the market.

Is the 2021 Mercedes-Benz E-Class reliable?

Owners rate it 4.7/5, a strong signal of long-term satisfaction.

User feedback points to a car that feels dependable, with owners highlighting its luxury, performance, and comfort in ways that suggest strong day-to-day confidence. The expert evaluation also describes it as a quiet and excellent choice for a car this size, with a do-it-all character that supports long-term usability.

The 48-volt hybridised powertrains are designed to improve efficiency and smoothness, and the model’s broad appeal suggests it should age well if it has been maintained properly. For used buyers, the main ownership risk is paying luxury-car repair costs if the vehicle has been poorly serviced or heavily optioned.

What should I look for when buying a used 2021 Mercedes-Benz E-Class?

Key things to evaluate:

• Trim level: The cabin is richly finished even in baser trims, but the Luxury package’s smaller wheels and softer-riding, slightly taller suspension are no longer part of the classic hood-ornament look. You should also note that the AMG models bring vertical grille slats, quad exhaust tips, and available 20-inch wheels, which make them feel more dramatic than the standard car.
• Powertrain: The E350 uses a 2.0-litre turbo four-cylinder that is described as underwhelming for a luxury car at this price, while the E450 uses a quiet and excellent electrified inline-six with 362 hp and 369 lb-ft. The AMG E53 adds more output and a faster, more urgent character, while the E63 S is a much more extreme V8 model.
• Safety package: Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. All other driver-assist features are optional, so you should check carefully for the equipment you want.
• Infotainment: The E-Class uses MBUX with a touch-enabled main screen, improved menu organisation, natural voice processing, online searches, and a digital instrument panel. The system does not update over-the-air, and standard Apple CarPlay and Android Auto are not wireless.
• Fuel efficiency: The E450 4Matic sedan returns 9.2 L/100 km combined, while the E350 4Matic sedan returns 9.4 L/100 km combined. The AMG models are thirstier, with the E53 sedan rated at 9.5 L/100 km combined and the E63 sedan at 12.8 L/100 km combined.

Which 2021 Mercedes-Benz E-Class trim should I buy?

The 2021 Mercedes-Benz E-Class is offered in 13 trim levels: E350, E450, AMG E53, and AMG E63 S.

Here's the short version:

• E350: This is the entry point, but the 2.0-litre turbo four-cylinder is described as underwhelming for a luxury car at this price. It makes sense only if you want the least expensive way into the E-Class experience.
• E450: This is the best-value choice for most buyers because it brings the quiet and excellent electrified inline-six, stronger output, and the same refined character the E-Class is known for. If you want the sweet spot, this is the one to target.
• AMG E53: Choose this if you want a sharper, faster version with brisk acceleration, rear-biased AWD, and variable-rate air suspension, while still keeping much of the E-Class comfort.
• AMG E63 S: This is the extreme choice, with a hand-built 4.0-litre V8, 603 hp, and a much more serious performance focus. It suits you only if you want the most powerful and most specialised E-Class.

Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard, while all other driver-assist features are optional.

Is now a good time to buy a used 2021 Mercedes-Benz E-Class?

This is a moderate market for selective buyers, so it rewards comparison shopping.

• Deal availability: 36.1% of listings are priced as good or great deals.
• Inventory: There are 83 listings available.
• Price trend: Prices have softened 21.96% compared with last year.

If you find a listing below $58,329 CAD, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Mercedes-Benz E-Class's resale value?

The current average of $60,331 CAD sits slightly below last year's $77,305 CAD.

That price drop suggests the market has already adjusted downward, which can help future sellers understand where buyer expectations now sit. If you buy at today's average, your resale position will depend heavily on condition, mileage, and equipment, because luxury-car shoppers tend to compare closely across similarly priced alternatives.

The softer pricing also means there may be less room for dramatic depreciation from here than there was a year ago, especially if the car remains desirable and well maintained. Vehicles with strong owner satisfaction ratings, like this model year's 4.7/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Mercedes-Benz E-Class safe?

The 2021 E-Class sedan and wagon scored a five-star overall rating and five stars in frontal and side crash tests and for rollover vulnerability from the U.S. National Highway Traffic Safety Administration (NHTSA). However, the driver's side received a four-star rating in the frontal crash test versus the full five stars for 2020.

It earns a 10/10 safety score from our experts.

Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. All other driver-assist features are optional, and some of them are not available from any other automaker. The 2020 E-Class sedan was rated a "Top Safety Pick+" by the Insurance Institute for Highway Safety (IIHS) with the highest ratings in six crash tests, headlights, and collision-avoidance systems.

Should I buy a 2021 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 36.1% of listings are priced as good or great deals.
• Price trend: Prices have softened 21.96% compared with last year.
• Owners rate it 4.7/5 — a strong satisfaction signal.
• The 2021 brings a mid-cycle update for the infotainment system, engines, and exterior styling.

Consider the 2022 if:

• At $53,469 CAD, the 2022 costs less than the current year's $60,331 CAD average.
• It changes little after the 2021 refresh, but rear USB charging ports become standard on coupe and convertible body styles.

The bottom line: If you want the most current-feeling version of this generation, the 2021 is the better all-around pick because it combines the refresh with strong owner satisfaction and a wide range of configurations. If your priority is lower purchase price and you are comfortable with a similar overall package, the 2022 is worth a look.

How does the 2021 Mercedes-Benz E-Class compare to the 2021 BMW 5 Series?

Our experts score the 2021 Mercedes-Benz E-Class 8.3/10 and the 2021 BMW 5 Series 8/10. The E-Class is the more versatile and more lavish-feeling choice, with a richer cabin and stronger technology score. The 5 Series is the cheaper used buy in this comparison, and it also has a higher share of good and great deals.

Read our full side-by-side expert comparison here.

These recommendations are based on CarGurus' proprietary market data from November 10, 2026, CarGurus experts' opinions, and generative AI.