2021 Toyota Sienna vs 2022 Mercedes-Benz GLS
Overview | |
MSRP$34,460 | MSRP$77,850 |
Listings92 | Listings15 |
Ratings & Reviews | |
User Reviews | User Reviews |
Expert reviews8.3 out of 10 | Expert reviews7.3 out of 10 |
2021 Toyota Sienna Reviews SummaryToyota’s minivan got a major makeover for 2021, now entering its fourth generation of production since debuting as a 1997 model. For the first time, the Sienna gets a hybrid gasoline-electric powertrain, and not only that—it’s standard equipment. The Sienna Hybrid is built on the Toyota New Global Architecture (TNGA-K) platform, shared with the Highlander and other current Toyota models. | |
2022 Mercedes-Benz GLS Reviews SummaryThe SUV that’s now known as the GLS was launched for the 2007 model year as the GL-Class, when Mercedes decided it needed a bigger, more luxurious SUV to sit above the M-Class in its lineup. The GL-Class and M-Class were rebadged the Mercedes-Benz GLS-Class and GLE-Class, respectively, in 2014 when Mercedes introduced a new naming scheme across its lineup. The current version of the GLS was introduced for the 2020 model year, and represents the model’s third generation. It’s aimed at other full-size luxury SUVs, including the BMW X7, Cadillac Escalade, Infiniti QX80, Land Rover Range Rover, Lincoln Navigator, and Lexus LX. Four models are available in Canada: the base six-cylinder GLS 450 4Matic, the GLS 580 4Matic, the AMG GLS 63 4Matic+, and the Mercedes-Maybach GLS 600 4Matic. Availability is currently limited, and specifications for the 2022 model year are not available. However, they are expected to be very close to those listed for 2021, which were used as reference for the information provided here. We tested a U.S.-specification 2022 GLS 450 for this review. | |
No video found | |
Popular Features & Specs | |
Engine2.5L 245 hp I4 Hybrid | Engine3.0L 362 hp I6 |
Drive TrainFWD | Drive TrainAWD |
Seating Capacity8 | Seating Capacity7 |
Horsepower | Horsepower362 hp @ 5500 rpm |
EV Battery Capacity1.9 kWh | EV Battery Capacity |
MPG City36 | MPG City18 |
MPG Highway36 | MPG Highway24 |
Engine | |
Engine Name2.5L 245 hp I4 Hybrid | Engine Name3.0L 362 hp I6 |
Torque | Torque369 lb-ft @ 1600 rpm |
Horsepower | Horsepower362 hp @ 5500 rpm |
DrivetrainFWD | DrivetrainAWD |
Fuel Economy | |
EV Battery Capacity1.9 kWh | EV Battery Capacity |
MPG City36 | MPG City18 |
MPG Highway36 | MPG Highway24 |
Interior | |
Seating Capacity8 | Seating Capacity7 |
Key Features | |
Navigation System | Navigation SystemStandard |
Sunroof/Moonroof | Sunroof/MoonroofStandard |
Safety | |
Front Crash Overall4 | Front Crash Overall |
Side Crash Overall5 | Side Crash Overall |
Dimensions & Capacity | |
Cargo Space33.5 cu ft | Cargo Space17.4 cu ft |
Curb Weight4610 lbs | Curb Weight5467 lbs |
Height68.5 in | Height72.4 in |
Length203.7 in | Length205.0 in |
Width78.5 in | Width84.9 in |
Wheelbase120.5 in | Wheelbase123.4 in |
Maximum Payload1560 lbs | Maximum Payload1808 lbs |
Number of doors4 | Number of doors4 |
Maximum Towing Capacity3500 lbs | Maximum Towing Capacity7700 lbs |
Overview | ||
MSRP | $34,460 | $77,850 |
Listings | ||
Ratings & Reviews | ||
User reviews | ||
Expert reviews | 8.3 out of 10Read full review | 7.3 out of 10Read full review |
Pros & cons | ||
Summary | Toyota’s minivan got a major makeover for 2021, now entering its fourth generation of production since debuting as a 1997 model. For the first time, the Sienna gets a hybrid gasoline-electric powertrain, and not only that—it’s standard equipment. The Sienna Hybrid is built on the Toyota New Global Architecture (TNGA-K) platform, shared with the Highlander and other current Toyota models. | The SUV that’s now known as the GLS was launched for the 2007 model year as the GL-Class, when Mercedes decided it needed a bigger, more luxurious SUV to sit above the M-Class in its lineup. The GL-Class and M-Class were rebadged the Mercedes-Benz GLS-Class and GLE-Class, respectively, in 2014 when Mercedes introduced a new naming scheme across its lineup. The current version of the GLS was introduced for the 2020 model year, and represents the model’s third generation. It’s aimed at other full-size luxury SUVs, including the BMW X7, Cadillac Escalade, Infiniti QX80, Land Rover Range Rover, Lincoln Navigator, and Lexus LX. Four models are available in Canada: the base six-cylinder GLS 450 4Matic, the GLS 580 4Matic, the AMG GLS 63 4Matic+, and the Mercedes-Maybach GLS 600 4Matic. Availability is currently limited, and specifications for the 2022 model year are not available. However, they are expected to be very close to those listed for 2021, which were used as reference for the information provided here. We tested a U.S.-specification 2022 GLS 450 for this review. |
Video | No video found | |
Popular Features & Specs | ||
Engine | 2.5L 245 hp I4 Hybrid | 3.0L 362 hp I6 |
Drive Train | FWD | AWD |
Seating Capacity | 8 | 7 |
Horsepower | 362 hp @ 5500 rpm | |
EV Battery Capacity | 1.9 kWh | |
MPG City | 36 | 18 |
MPG Highway | 36 | 24 |
Engine | ||
Engine Name | 2.5L 245 hp I4 Hybrid | 3.0L 362 hp I6 |
Torque | 369 lb-ft @ 1600 rpm | |
Horsepower | 362 hp @ 5500 rpm | |
Drivetrain | FWD | AWD |
Fuel Economy | ||
EV Battery Capacity | 1.9 kWh | |
MPG City | 36 | 18 |
MPG Highway | 36 | 24 |
Interior | ||
Seating Capacity | 8 | 7 |
Key Features | ||
Navigation System | Standard | |
Sunroof/Moonroof | Standard | |
Safety | ||
Front Crash Overall | 4 | |
Side Crash Overall | 5 | |
Dimensions & Capacity | ||
Cargo Space | 33.5 cu ft | 17.4 cu ft |
Curb Weight | 4610 lbs | 5467 lbs |
Height | 68.5 in | 72.4 in |
Length | 203.7 in | 205.0 in |
Width | 78.5 in | 84.9 in |
Wheelbase | 120.5 in | 123.4 in |
Maximum Payload | 1560 lbs | 1808 lbs |
Number of doors | 4 | 4 |
Maximum Towing Capacity | 3500 lbs | 7700 lbs |
The 2021 Toyota Sienna aimed to redefine the minivan aesthetic with its SUV-like styling. It featured a wide grille and sleek LED headlamp arrays that integrated seamlessly with the Toyota logo, giving it a modern and assertive stance. The redesigned sliding side doors added a sculpted look, enhancing the vehicle's overall appeal. Alloy wheels ranging from 17 to 20 inches complemented the Sienna's exterior, while the interior emphasized width with horizontal lines. The dashboard was simple and uncluttered, and the centre console offered practical storage solutions. The seating was comfortable, with the second and third rows providing ample space for adults, making the Sienna a practical choice for families.
In contrast, the 2022 Mercedes-Benz GLS presented a more subtle luxury SUV appearance, especially in its base GLS 450 form. It avoided the flashy grilles of some competitors, offering a refined look. The AMG GLS 63 and Maybach versions added visual drama with features like flared wheel arches and chrome accents. Inside, the GLS boasted a luxurious feel with leather upholstery, a panoramic roof, and ambient lighting. The digital instrument cluster and infotainment touchscreen were well-integrated, enhancing the vehicle's modern appeal. While the GLS's interior was high-quality, it was perhaps too subdued for those seeking a more opulent experience.















The 2021 Toyota Sienna Hybrid marked Toyota's first foray into hybrid minivans, featuring a 2.5-litre four-cylinder engine paired with two electric motors, producing a combined 243 horsepower. It offered both front-wheel drive and all-wheel drive options, with the latter using a separate electric motor for the rear wheels. The Sienna's electronically controlled CVT aimed to maximize fuel efficiency, though it sometimes dulled throttle response. The vehicle's handling was improved with new suspension systems, and it boasted impressive fuel efficiency ratings, with FWD models achieving 6.6 litres per 100 kilometres in the city.
The 2022 Mercedes-Benz GLS 450 featured a 3.0-litre turbocharged inline six-cylinder engine with a nine-speed automatic transmission, producing 362 horsepower and 369 pound-feet of torque. The EQ Boost mild-hybrid system added short bursts of power, enhancing performance. While the GLS 450's engine provided ample power, the air suspension's poor body control detracted from the ride quality. The GLS 450 had a towing capacity of 3,500 kilograms, though it fell short of some competitors. Despite these drawbacks, the inline-six engine offered a smooth and balanced driving experience.
The 2021 Toyota Sienna excelled in convenience and functionality, with a standard third-row 60/40-split bench that folded into the floor. The second row could slide up to 63.5 centimetres, providing flexible legroom and easy access to the third row. The Sienna offered ample storage, with 16 cupholders and the ability to carry a full four-by-eight sheet of plywood. Cargo space was generous, with up to 2,860 litres available. The hybrid battery was cleverly positioned under the front seats, preserving cargo space. Power-operated sliding doors and a rear liftgate added to the Sienna's family-friendly features.
The 2022 Mercedes-Benz GLS offered a seven-seat configuration with a 60/40 split-folding second-row bench and two third-row seats. An optional six-seat version replaced the bench with captain's chairs. The second-row seats could slide forward, providing excellent legroom. Cargo space was competitive, with up to 2,400 litres available with the second and third rows folded. The GLS featured one-touch power-folding seats and a power tailgate, making loading and unloading easy. However, some ergonomic issues, like the touchscreen's reach and small sun visors, detracted from the overall experience.
The 2021 Toyota Sienna came equipped with a nine-inch touchscreen, offering Apple CarPlay and Android Auto compatibility. It included a range of connectivity features, such as Safety Connect and Remote Connect trials, Bluetooth, and Qi-compatible charging on higher trims. The audio system varied by trim, with a Premium Audio + JBL package available. A rear-seat entertainment system was also offered, enhancing the Sienna's family appeal. The driver benefited from tech features like a digital rearview mirror and remote keyless entry.
The 2022 Mercedes-Benz GLS featured the MBUX infotainment system with a 12.3-inch touchscreen and digital instrument cluster. It offered Bluetooth, Apple CarPlay/Android Auto connectivity, and navigation. The voice recognition system was particularly effective, allowing for hands-free operation. However, the touchpad controller was cumbersome, and the navigation system occasionally suggested inefficient routes. Despite these issues, the GLS's graphics and augmented-reality navigation were impressive.
The 2021 Toyota Sienna Hybrid included Toyota Safety Sense 2.0, offering features like adaptive cruise control, lane-tracing assist, and a pre-collision system. It also had the Star Safety System and blind spot monitoring. The Sienna was equipped with 10 airbags and LATCH connectors for child seats. It received a "Top Safety Pick+" rating from the IIHS and a Five-Star Overall Rating from NHTSA.
The 2022 Mercedes-Benz GLS offered a comprehensive suite of standard safety features, including forward collision warning, automatic emergency braking, and blind-spot monitoring. Additional features like adaptive cruise control and advanced driver-assistance systems were optional. Crash-test ratings from the IIHS and NHTSA were not available at the time of publication.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Toyota Sienna is 8.3 out of 10, while the 2022 Mercedes-Benz GLS scores 7.3 out of 10. Based on these ratings, the Toyota Sienna emerges as the recommended choice, offering a superior blend of practicality, efficiency, and safety for families.
Choose the 2021 Toyota Sienna if:
- You prioritize fuel efficiency and hybrid technology in a family vehicle.
- You need a versatile interior with ample cargo space and seating flexibility.
- You value comprehensive safety features and high safety ratings.
Choose the 2022 Mercedes-Benz GLS if:
- You desire a luxury SUV with a refined and subtle design.
- You appreciate advanced infotainment technology and voice recognition.
- You seek a smooth and powerful driving experience with a mild-hybrid system.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Toyota Sienna is 8.3 out of 10, while the 2022 Mercedes-Benz GLS scores 7.3 out of 10. Based on these ratings, the Toyota Sienna emerges as the recommended choice, offering a superior blend of practicality, efficiency, and safety for families.
Choose the 2021 Toyota Sienna if:
Shop Now- You prioritize fuel efficiency and hybrid technology in a family vehicle.
- You need a versatile interior with ample cargo space and seating flexibility.
- You value comprehensive safety features and high safety ratings.
Choose the 2022 Mercedes-Benz GLS if:
Shop Now- You desire a luxury SUV with a refined and subtle design.
- You appreciate advanced infotainment technology and voice recognition.
- You seek a smooth and powerful driving experience with a mild-hybrid system.

By: CarGurus + AI
At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.



































