2021 Mercedes-Benz GLS vs 2022 Honda Odyssey
Overview | |
MSRP$76,000 | MSRP$33,040 |
Listings16 | Listings88 |
Ratings & Reviews | |
User Reviews | User Reviews |
Expert reviews8.3 out of 10 | Expert reviews7.0 out of 10 |
2021 Mercedes-Benz GLS Reviews SummaryThe “S” in the 2021 Mercedes-Benz GLS name is meant to connect the SUV to the S-Class flagship sedan. In this sense, the GLS is the S-Class of SUVs, and it delivers on that positioning. The 2021 GLS-Class has three rows of spacious seating, and puts comfort above all else. The GLS can hold groceries, weekend bags, antique desks purchased from a roadside consignment shop—all things that would require a lot of negotiating in the S-Class sedan. The GLS is one member of a growing fraternity of full-size, three-row, luxury SUVs. Their ranks include the Cadillac Escalade, Lincoln Navigator, Infiniti QX80, and the more recent BMW X7. The GLS sets itself apart with a higher standard of luxury, and impressive performance… if you’re willing to shell out the cash. | |
2022 Honda Odyssey Reviews SummaryIf you are a minivan aficionado like we are, then you know that the 2022 Honda Odyssey is the most enjoyable one to drive. It has that light, effortless, responsive driving character that Honda bakes into every one of its cars, trucks, SUVs, and minivans. But you also know that the Odyssey’s rivals are successfully outflanking it in terms of stylish design, all-weather capability, electrified efficiency, infotainment technology, and outright luxury. In response to these new threats, Honda makes no changes to the 2022 Odyssey. Good thing its “original recipe” approach remains pretty tasty. | |
No video found | No video found |
Popular Features & Specs | |
Engine3.0L 362 hp I6 | Engine3.5L 280 hp V6 |
Drive TrainAWD | Drive TrainFWD |
Seating Capacity7 | Seating Capacity7 |
Horsepower362 hp @ 5500 rpm | Horsepower280 hp @ 6000 rpm |
MPG City20 | MPG City19 |
MPG Highway24 | MPG Highway28 |
Engine | |
Engine Name3.0L 362 hp I6 | Engine Name3.5L 280 hp V6 |
Torque369 lb-ft @ 1600 rpm | Torque262 lb-ft @ 4700 rpm |
Horsepower362 hp @ 5500 rpm | Horsepower280 hp @ 6000 rpm |
DrivetrainAWD | DrivetrainFWD |
Fuel Economy | |
MPG City20 | MPG City19 |
MPG Highway24 | MPG Highway28 |
Interior | |
Seating Capacity7 | Seating Capacity7 |
Key Features | |
Navigation SystemStandard | Navigation System |
Sunroof/MoonroofStandard | Sunroof/Moonroof |
Safety | |
Front Crash Overall | Front Crash Overall5 |
Side Crash Overall | Side Crash Overall5 |
Dimensions & Capacity | |
Cargo Space17.4 cu ft | Cargo Space32.8 cu ft |
Curb Weight5467 lbs | Curb Weight4398 lbs |
Height72.4 in | Height68.3 in |
Length205.0 in | Length205.2 in |
Width84.9 in | Width78.5 in |
Wheelbase123.4 in | Wheelbase118.1 in |
Maximum Payload1808 lbs | Maximum Payload1621 lbs |
Number of doors4 | Number of doors4 |
Maximum Towing Capacity7700 lbs | Maximum Towing Capacity3500 lbs |
Overview | ||
MSRP | $76,000 | $33,040 |
Listings | ||
Ratings & Reviews | ||
User reviews | ||
Expert reviews | 8.3 out of 10Read full review | 7.0 out of 10Read full review |
Pros & cons | ||
Summary | The “S” in the 2021 Mercedes-Benz GLS name is meant to connect the SUV to the S-Class flagship sedan. In this sense, the GLS is the S-Class of SUVs, and it delivers on that positioning. The 2021 GLS-Class has three rows of spacious seating, and puts comfort above all else. The GLS can hold groceries, weekend bags, antique desks purchased from a roadside consignment shop—all things that would require a lot of negotiating in the S-Class sedan. The GLS is one member of a growing fraternity of full-size, three-row, luxury SUVs. Their ranks include the Cadillac Escalade, Lincoln Navigator, Infiniti QX80, and the more recent BMW X7. The GLS sets itself apart with a higher standard of luxury, and impressive performance… if you’re willing to shell out the cash. | If you are a minivan aficionado like we are, then you know that the 2022 Honda Odyssey is the most enjoyable one to drive. It has that light, effortless, responsive driving character that Honda bakes into every one of its cars, trucks, SUVs, and minivans. But you also know that the Odyssey’s rivals are successfully outflanking it in terms of stylish design, all-weather capability, electrified efficiency, infotainment technology, and outright luxury. In response to these new threats, Honda makes no changes to the 2022 Odyssey. Good thing its “original recipe” approach remains pretty tasty. |
Video | No video found | No video found |
Popular Features & Specs | ||
Engine | 3.0L 362 hp I6 | 3.5L 280 hp V6 |
Drive Train | AWD | FWD |
Seating Capacity | 7 | 7 |
Horsepower | 362 hp @ 5500 rpm | 280 hp @ 6000 rpm |
MPG City | 20 | 19 |
MPG Highway | 24 | 28 |
Engine | ||
Engine Name | 3.0L 362 hp I6 | 3.5L 280 hp V6 |
Torque | 369 lb-ft @ 1600 rpm | 262 lb-ft @ 4700 rpm |
Horsepower | 362 hp @ 5500 rpm | 280 hp @ 6000 rpm |
Drivetrain | AWD | FWD |
Fuel Economy | ||
MPG City | 20 | 19 |
MPG Highway | 24 | 28 |
Interior | ||
Seating Capacity | 7 | 7 |
Key Features | ||
Navigation System | Standard | |
Sunroof/Moonroof | Standard | |
Safety | ||
Front Crash Overall | 5 | |
Side Crash Overall | 5 | |
Dimensions & Capacity | ||
Cargo Space | 17.4 cu ft | 32.8 cu ft |
Curb Weight | 5467 lbs | 4398 lbs |
Height | 72.4 in | 68.3 in |
Length | 205.0 in | 205.2 in |
Width | 84.9 in | 78.5 in |
Wheelbase | 123.4 in | 118.1 in |
Maximum Payload | 1808 lbs | 1621 lbs |
Number of doors | 4 | 4 |
Maximum Towing Capacity | 7700 lbs | 3500 lbs |
The 2021 Mercedes-Benz GLS, a continuation of the third generation introduced in 2020, was a luxurious SUV that evolved from the original GL-Class. It was designed to replace the G-Class, but the latter's popularity kept it in the market, leading the GLS to cater to affluent families seeking a comfortable, three-row alternative to the Navigator and Escalade. The GLS featured a sleek design with softened angles and a futuristic interior dominated by a massive digital screen, emphasizing its tech-centric approach. Available in three trims—GLS 450, GLS 580, and the high-performance AMG GLS 63—the GLS offered a range of standard features, including remote keyless entry, nine USB ports, and a premium sound system, with various option packages to enhance luxury and performance.
In contrast, the 2022 Honda Odyssey was a practical choice for families, offering the convenience of sliding side doors and a spacious, comfortable third-row seat. Despite the minivan's image challenges, the Odyssey maintained a sense of style with its kinked sliding doors and clean design lines. The Touring trim, which we tested, featured quality leather upholstery, a low console for an open-concept feel, and ample storage space. The Odyssey's interior was designed for family use, with features like tri-colour floor mats and an onboard vacuum cleaner. The Magic Slide second-row seats provided flexibility for child safety and easy access to the third row, making the Odyssey a versatile and family-friendly vehicle.















The 2021 Mercedes-Benz GLS offered a range of powerful engines, starting with the GLS 450's twin-turbocharged 3.0-litre inline-six engine, producing 362 horsepower and 369 pound-feet of torque. The GLS 580 4MATIC featured a twin-turbocharged 4.0-litre V8, delivering 483 hp and 516 lb-ft. Both models used a nine-speed automatic transmission with Mercedes' 4MATIC AWD system. The AMG GLS 63, with its hand-crafted 4.0-litre twin-turbo V8 engine, boasted 603 hp and 627 lb-ft of torque, achieving 0-100 km/h in just 4.2 seconds. The GLS 63's adaptive air suspension and multiple drive modes provided a smooth and agile driving experience, defying its size and weight.
The 2022 Honda Odyssey, powered by a 3.5-litre V6 engine, offered 280 horsepower and 262 pound-feet of torque, paired with a 10-speed automatic transmission. Unlike some competitors, the Odyssey lacked AWD and hybrid options, resulting in a fuel consumption estimate of 10.6 L/100 km. Despite this, the Odyssey was enjoyable to drive, with responsive handling and quick acceleration. However, its brakes tended to overheat on downhill grades, affecting performance. Overall, the Odyssey provided a pleasant driving experience, but its braking system required improvement for better safety and reliability.
The 2021 Mercedes-Benz GLS provided spacious seating across three rows, with ample headroom and legroom for first- and second-row passengers. The third row, while less spacious, was still suitable for adults. The GLS offered 355 litres of cargo space behind the third row, expanding to 1,209 litres with the third row folded, and 2,400 litres with both rear rows down. The interior featured numerous storage compartments, including a centre console with butterfly doors, though it was not large enough for a purse.
The 2022 Honda Odyssey excelled in interior space and functionality, with wide-opening doors and a low seating position for easy access. The Touring trim featured quality leather seats, tri-zone climate control, and ample storage options. The Magic Slide second-row seats allowed for flexible configurations, enhancing safety and convenience. The third-row seat was comfortable for adults, with 929 litres of cargo space behind it. Folding the third row increased cargo capacity to 2,452 litres, and removing the second row provided a massive 3,984 litres of space, rivaling larger SUVs.
The 2021 Mercedes-Benz GLS featured the MBUX infotainment system with a large touch screen and voice-control capabilities. It included Apple CarPlay and Android Auto connectivity, though a USB-C cable was required. The digital dash extended to the instrument panel, controlled by touch-sensitive pads on the steering wheel. While the system had a learning curve, it offered a comprehensive tech experience once mastered.
The 2022 Honda Odyssey's technology package, while comprehensive, was becoming outdated compared to rivals. The 8-inch touchscreen infotainment system included Apple CarPlay, Android Auto, and navigation, but lacked modern features like a larger screen or tuning knob. The Touring trim added CabinWatch and CabinTalk systems, a rear entertainment system, and a premium audio system. However, the Odyssey's infotainment and technology offerings needed significant updates to remain competitive.
The 2021 Mercedes-Benz GLS came standard with numerous driver-assistance features, including Active Brake Assist, automatic high beams, and crosswind assist. Optional safety tech included lane-change assist, adaptive cruise control, and blind spot monitoring. The GLS was equipped with a full array of airbags, traction control, and a tire-pressure monitoring system.
The 2022 Honda Odyssey featured Honda Sensing as standard, offering adaptive cruise control, forward-collision warning, automatic emergency braking, and lane-keeping assist. However, the system lacked refinement, occasionally issuing false warnings or taking abrupt actions. The Odyssey earned a five-star rating from the NHTSA and a Top Safety Pick+ from the IIHS, but its safety features required improvement for a more natural driving experience.
CarGurus highlights

According to CarGurus experts, the overall rating for 2021 Mercedes-Benz GLS is 8.3 out of 10, while the 2022 Honda Odyssey scores 7.0 out of 10. Based on these ratings, the 2021 Mercedes-Benz GLS is the recommended choice for those seeking a luxurious and powerful SUV with advanced technology and a spacious interior.
Choose the 2021 Mercedes-Benz GLS if:
- You desire a luxury SUV with powerful engine options and advanced technology.
- You need a spacious interior with flexible seating and ample cargo space.
- You value a smooth and agile driving experience with multiple drive modes.
Choose the 2022 Honda Odyssey if:
- You require a family-friendly vehicle with sliding doors and comfortable third-row seating.
- You need a versatile interior with flexible seating configurations and ample storage.
- You prioritize safety features and crash-test ratings for family protection.
CarGurus highlights

According to CarGurus experts, the overall rating for 2021 Mercedes-Benz GLS is 8.3 out of 10, while the 2022 Honda Odyssey scores 7.0 out of 10. Based on these ratings, the 2021 Mercedes-Benz GLS is the recommended choice for those seeking a luxurious and powerful SUV with advanced technology and a spacious interior.
Choose the 2021 Mercedes-Benz GLS if:
Shop Now- You desire a luxury SUV with powerful engine options and advanced technology.
- You need a spacious interior with flexible seating and ample cargo space.
- You value a smooth and agile driving experience with multiple drive modes.
Choose the 2022 Honda Odyssey if:
Shop Now- You require a family-friendly vehicle with sliding doors and comfortable third-row seating.
- You need a versatile interior with flexible seating configurations and ample storage.
- You prioritize safety features and crash-test ratings for family protection.

By: CarGurus + AI
At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.



































