2021 Mercedes-Benz E-Class vs 2022 Lexus IS
Overview | |
MSRP$54,250 | MSRP$39,125 |
Listings19 | Listings30 |
Ratings & Reviews | |
User Reviews | User Reviews |
Expert reviews8.3 out of 10 | Expert reviews8.2 out of 10 |
2021 Mercedes-Benz E-Class Reviews SummaryWhen money is but a mild concern, a brand-new Mercedes-Benz is a reasonable purchase. The Mercedes-Benz E-Class is the company's most practical and versatile car, as high-quality and necessary in a nice garage as a Kitchen-Aid mixer is in a baker's kitchen. It offers four body styles, four engines, and dozens of colour schemes. Fast or efficient? Loud or library quiet? Modest or rich as hell? The E-Class, the brand's midsize car, is all of those things, depending on which of the 13 models you order and how deep into the options list you dive. For 2021, the E-Class receives a mid-cycle update for the infotainment system, engines, and exterior styling. We tested the Mercedes-AMG E53 that features a mild-hybrid inline-6 powertrain. | |
2022 Lexus IS Reviews SummaryAfter a substantial refresh for the 2021 model year, the 2022 Lexus IS lineup returns with a handful of minor updates and a significant improvement in performance. The new Lexus IS 500 F Sport Performance also debuts this year, packing a normally aspirated 5.0-litre V8 and laugh-riot driving dynamics. If you’re among the driving enthusiasts who miss the discontinued Lexus GS F, this is a credible substitute. | |
No video found | |
Popular Features & Specs | |
Engine2.0L 255 hp I4 | Engine2.0L 241 hp I4 |
Drive TrainRWD | Drive TrainRWD |
Seating Capacity5 | Seating Capacity5 |
Horsepower255 hp @ 5800 rpm | Horsepower241 hp @ 5800 rpm |
MPG City22 | MPG City21 |
MPG Highway31 | MPG Highway31 |
Engine | |
Engine Name2.0L 255 hp I4 | Engine Name2.0L 241 hp I4 |
Torque273 lb-ft @ 1800 rpm | Torque258 lb-ft @ 1650 rpm |
Horsepower255 hp @ 5800 rpm | Horsepower241 hp @ 5800 rpm |
DrivetrainRWD | DrivetrainRWD |
Fuel Economy | |
MPG City22 | MPG City21 |
MPG Highway31 | MPG Highway31 |
Interior | |
Seating Capacity5 | Seating Capacity5 |
Key Features | |
Navigation SystemStandard | Navigation System |
Sunroof/MoonroofStandard | Sunroof/Moonroof |
Safety | |
Front Crash Overall5 | Front Crash Overall4 |
Side Crash Overall5 | Side Crash Overall5 |
Dimensions & Capacity | |
Cargo Space13.1 cu ft | Cargo Space10.8 cu ft |
Curb Weight3781 lbs | Curb Weight3715 lbs |
Height57.8 in | Height56.5 in |
Length194.3 in | Length185.4 in |
Width81.3 in | Width72.4 in |
Wheelbase115.7 in | Wheelbase110.2 in |
Maximum Payload | Maximum Payload825 lbs |
Number of doors4 | Number of doors4 |
Overview | ||
MSRP | $54,250 | $39,125 |
Listings | ||
Ratings & Reviews | ||
User reviews | ||
Expert reviews | 8.3 out of 10Read full review | 8.2 out of 10Read full review |
Pros & cons | ||
Summary | When money is but a mild concern, a brand-new Mercedes-Benz is a reasonable purchase. The Mercedes-Benz E-Class is the company's most practical and versatile car, as high-quality and necessary in a nice garage as a Kitchen-Aid mixer is in a baker's kitchen. It offers four body styles, four engines, and dozens of colour schemes. Fast or efficient? Loud or library quiet? Modest or rich as hell? The E-Class, the brand's midsize car, is all of those things, depending on which of the 13 models you order and how deep into the options list you dive. For 2021, the E-Class receives a mid-cycle update for the infotainment system, engines, and exterior styling. We tested the Mercedes-AMG E53 that features a mild-hybrid inline-6 powertrain. | After a substantial refresh for the 2021 model year, the 2022 Lexus IS lineup returns with a handful of minor updates and a significant improvement in performance. The new Lexus IS 500 F Sport Performance also debuts this year, packing a normally aspirated 5.0-litre V8 and laugh-riot driving dynamics. If you’re among the driving enthusiasts who miss the discontinued Lexus GS F, this is a credible substitute. |
Video | No video found | |
Popular Features & Specs | ||
Engine | 2.0L 255 hp I4 | 2.0L 241 hp I4 |
Drive Train | RWD | RWD |
Seating Capacity | 5 | 5 |
Horsepower | 255 hp @ 5800 rpm | 241 hp @ 5800 rpm |
MPG City | 22 | 21 |
MPG Highway | 31 | 31 |
Engine | ||
Engine Name | 2.0L 255 hp I4 | 2.0L 241 hp I4 |
Torque | 273 lb-ft @ 1800 rpm | 258 lb-ft @ 1650 rpm |
Horsepower | 255 hp @ 5800 rpm | 241 hp @ 5800 rpm |
Drivetrain | RWD | RWD |
Fuel Economy | ||
MPG City | 22 | 21 |
MPG Highway | 31 | 31 |
Interior | ||
Seating Capacity | 5 | 5 |
Key Features | ||
Navigation System | Standard | |
Sunroof/Moonroof | Standard | |
Safety | ||
Front Crash Overall | 5 | 4 |
Side Crash Overall | 5 | 5 |
Dimensions & Capacity | ||
Cargo Space | 13.1 cu ft | 10.8 cu ft |
Curb Weight | 3781 lbs | 3715 lbs |
Height | 57.8 in | 56.5 in |
Length | 194.3 in | 185.4 in |
Width | 81.3 in | 72.4 in |
Wheelbase | 115.7 in | 110.2 in |
Maximum Payload | 825 lbs | |
Number of doors | 4 | 4 |
The 2021 Mercedes-Benz E-Class, part of the W213 generation, was a testament to the brand's "sensual purity" design philosophy. It moved away from the sharper lines of its predecessor to embrace a more fluid and curvier aesthetic, reminiscent of the S-Class and C-Class models. The E-Class featured a slightly edgier front with squinted headlights and an inverted trapezoid grille, while the rear design echoed the W212 with horizontal taillights. Despite the absence of the classic standing hood ornament, the E-Class maintained its elegance across its sedan, wagon, coupe, and convertible variants. Inside, the E-Class was a showcase of luxury, with rich woods, aluminum, and carbon fibre adorning the cabin. The dual 12-inch screens provided a modern touch, while the lavish materials and ambient lighting created an inviting atmosphere.
In contrast, the 2022 Lexus IS 500 F Sport Performance carried forward the legacy of the original IS F with its powerful 5.0-litre V8 engine. The exterior design was subtle, with minor trim modifications and exclusive 19-inch alloy wheels, maintaining a stealthy appearance. Inside, the IS 500 offered a snug yet comfortable interior, with bolstered front seats and adequate rear seating for average-sized adults. The cabin was equipped with a touchscreen infotainment system, enhancing usability. Despite its compact size, the IS 500 provided a satisfying driving experience, blending comfort with performance.
















The 2021 Mercedes-Benz E-Class introduced electrified inline-six powertrains, replacing the conventional V6 engines. The E450 model became a hybrid, utilizing a 48-volt electrical system to supplement the 12-volt system. This setup provided an additional 21 horsepower and 184 lb-ft of torque for brief moments, enhancing fuel efficiency and reducing emissions. The E450's 3.0-litre I6 engine produced 362 hp and 369 lb-ft of torque, with overboost capabilities. The AMG E53 model added a second turbo, delivering 429 hp and 384 lb-ft of torque, while the AMG E63 S boasted a 4.0-litre V8 engine with 603 hp and 627 lb-ft of torque. Despite its power, the E-Class prioritized comfort over sportiness, offering a smooth and stable ride.
The 2022 Lexus IS 500 F Sport Performance featured a 5.0-litre V8 engine, producing 472 hp and 395 lb-ft of torque. The engine was paired with an eight-speed automatic transmission and a limited-slip differential, providing a dynamic driving experience. The IS 500's adaptive variable suspension and Yamaha rear performance damper ensured a comfortable ride, while the upgraded brakes offered reliable stopping power. The IS 500 accelerated from 0 to 60 mph in 4.4 seconds, delivering an exhilarating performance. However, its fuel efficiency was less impressive, averaging 13.3 L/100 km during testing.
The 2021 Mercedes-Benz E-Class offered a spacious cabin with ample headroom and legroom for four adults. The interior featured supportive cushions, knee cutouts, and a scalloped roof for taller passengers. The E-Class Coupe provided comfortable rear seats, while the convertible's rear seats were less accommodating. The wagon variant offered a stowable rear-facing jump seat and significant cargo space, with 640 litres or 1,820 litres with seats folded. The sedan's trunk space measured 540 litres, while the two-door models offered 405 litres. The E-Class All-Terrain wagon added ground clearance and plastic body cladding for a rugged look.
The 2022 Lexus IS 500 F Sport Performance prioritized comfort with its effective climate control system, seat heaters, and a heated steering wheel. The front seats were snug yet comfortable, offering excellent thigh support and a driver-focused position. The rear seats accommodated average-sized adults, with rear air conditioning vents but no smartphone charging. The trunk space was limited to 305 litres, which was small for a compact car. The IS 500's control layout was intuitive, with buttons and knobs clearly marked, complementing the touchscreen infotainment system.
The 2021 Mercedes-Benz E-Class featured the MBUX infotainment system, offering a touchscreen interface with organized menus and shortcut buttons. Gesture controls and natural voice processing enhanced usability, while the system provided live camera feeds and augmented reality navigation. Optional features included massaging seats, seat kinetics, and a wireless phone charger. The instrument cluster offered customizable displays, allowing drivers to choose between traditional or modern graphics. Despite lacking over-the-air updates, the E-Class provided a comprehensive suite of connected services and optional driving assists.
The 2022 Lexus IS 500 F Sport Performance introduced a touchscreen infotainment system, improving ergonomics and usability. The dynamic voice command system handled queries accurately, while standard features included an 8-inch touchscreen, Apple CarPlay, Android Auto, and a Wi-Fi hotspot. The IS 500 added a 10.3-inch touchscreen, navigation, and a 17-speaker Mark Levinson audio system, delivering impressive sound quality. The intuitive controls and logical layout made the IS 500's technology user-friendly and satisfying.
The 2021 Mercedes-Benz E-Class was a leader in safety, earning a five-star overall rating from the NHTSA and a "Top Safety Pick+" from the IIHS. The E-Class featured innovative safety technologies, such as Pre-Safe Sound and side bolster inflation during collisions. Standard safety features included forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring, with 14 optional driver-assist features available.
The 2022 Lexus IS 500 F Sport Performance came equipped with Lexus Safety System+ 2.5, offering a comprehensive suite of safety features. The system included driving assistance, collision warning, and emergency braking technologies. The IS 500 received a "Top Safety Pick+" rating from the IIHS and a five-star overall rating from the NHTSA. While some safety features were helpful, others could be intrusive, such as the low-speed automatic braking in city traffic.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz E-Class is 8.3 out of 10, while the 2022 Lexus IS scores 8.2 out of 10. Based on these ratings, the 2021 Mercedes-Benz E-Class is the recommended choice for those seeking a luxurious and technologically advanced vehicle with a focus on comfort and safety.
Choose the 2021 Mercedes-Benz E-Class if:
- You prioritize a luxurious and spacious interior with advanced technology.
- You seek a comfortable ride with a focus on elegance and refinement.
- You value a comprehensive suite of safety features and high safety ratings.
Choose the 2022 Lexus IS if:
- You desire a powerful V8 engine with thrilling performance capabilities.
- You appreciate a user-friendly infotainment system with intuitive controls.
- You want a compact sports sedan with a distinctive design and engaging driving experience.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Mercedes-Benz E-Class is 8.3 out of 10, while the 2022 Lexus IS scores 8.2 out of 10. Based on these ratings, the 2021 Mercedes-Benz E-Class is the recommended choice for those seeking a luxurious and technologically advanced vehicle with a focus on comfort and safety.
Choose the 2021 Mercedes-Benz E-Class if:
Shop Now- You prioritize a luxurious and spacious interior with advanced technology.
- You seek a comfortable ride with a focus on elegance and refinement.
- You value a comprehensive suite of safety features and high safety ratings.
Choose the 2022 Lexus IS if:
Shop Now- You desire a powerful V8 engine with thrilling performance capabilities.
- You appreciate a user-friendly infotainment system with intuitive controls.
- You want a compact sports sedan with a distinctive design and engaging driving experience.

By: CarGurus + AI
At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.






































