Used 2021 GMC Sierra 2500HD for SaleNationwide

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87 vehicles found
Year:
2022
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
6.6L V8 Biodiesel
Fuel type:
Biodiesel
Transmission:
Automatic
Mileage:
143,464
Stock #:
T295953
VIN:
1GT19REY3NF295953
 2022 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic

 

2022 GMC Sierra 2500HD

Denali Crew Cab 4WD

143,464 km

Woodbridge, ON
Great Deal

$59,795

Year:
2022
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
6.6L V8 Biodiesel
Exterior colour:
Blue
Fuel type:
Biodiesel
Transmission:
Automatic
Mileage:
162,418
Stock #:
304633
VIN:
1GT49REY3NF287980
Blue 2022 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic
New arrival

 

2022 GMC Sierra 2500HD

Denali Crew Cab 4WD

162,418 km

Lethbridge, AB
Great Deal

$59,499

Year:
2021
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
401 hp 6.6L V8
Exterior colour:
White
Fuel type:
Gasoline
Interior colour:
Black
Transmission:
Automatic
Mileage:
94,134
Stock #:
73290
VIN:
1GT49RE78MF210723
White 2021 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic
New arrival

 

2021 GMC Sierra 2500HD

Denali Crew Cab 4WD

94,134 km

Rocky Mountain House, AB
Great Deal
Certified Pre-Owned

$63,995

Year:
2021
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
401 hp 6.6L V8
Exterior colour:
White
Fuel type:
Gasoline
Transmission:
Automatic
Mileage:
242,215
Stock #:
R104378
VIN:
1GT49LE76MF238548
White 2021 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic

 

2021 GMC Sierra 2500HD

Base Crew Cab 4WD

242,215 km

Saskatoon, SK
Great Deal

$31,995

Year:
2022
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Exterior colour:
Black
Transmission:
Automatic
Mileage:
129,929
Stock #:
R1067A
VIN:
1GT49REY7NF131196
Black 2022 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic

 

2022 GMC Sierra 2500HD

Denali Crew Cab 4WD

129,929 km

Québec, QC
Great Deal

$59,959

Year:
2022
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Exterior colour:
Black
Transmission:
Automatic
Mileage:
64,486
Stock #:
W3712
VIN:
1GT19LEY2NF326476
Black 2022 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic

 

2022 GMC Sierra 2500HD

Pro Crew Cab 4WD

64,486 km

Saint-Basile-Le-Grand, QC
Good Deal

$54,989

Year:
2022
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
6.6L V8 Biodiesel
Exterior colour:
Black
Fuel type:
Biodiesel
Transmission:
Automatic
Mileage:
125,000
Stock #:
P921
VIN:
1GT49REY5NF359746
Black 2022 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic

 

2022 GMC Sierra 2500HD

Denali Crew Cab 4WD

125,000 km

Edmonton, AB
Good Deal

$65,916

Year:
2021
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
401 hp 6.6L V8
Exterior colour:
White
Fuel type:
Gasoline
Transmission:
Automatic
Mileage:
93,870
Stock #:
N0310
VIN:
1GT49LE71MF247660
White 2021 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic

 

2021 GMC Sierra 2500HD

Base Crew Cab 4WD

93,870 km

Mirabel, QC
Good Deal

$44,990

CarGurus Analysis:

2021 GMC Sierra 2500HD

5.0

  • With 90 currently listed for sale and an average price of $58,243 CAD, 33.3% of 2021 GMC Sierras 2500HD for sale on CarGurus are rated as good or great deals.

  • Favourably reviewed: Owners rated the 2021 GMC Sierra 2500HD 5 / 5 stars.

  • 100.0% of 2021 Sierra 2500HD models on CarGurus are accident free.

Research summarized using AI

Year:
2022
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
401 hp 6.6L V8
Fuel type:
Gasoline
Transmission:
Automatic
Mileage:
81,393
Stock #:
A15701
VIN:
1GT19ME72NF359359
 2022 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic
New arrival

 

2022 GMC Sierra 2500HD

SLE Crew Cab 4WD

81,393 km

Blainville, QC
Good Deal

$49,995

Year:
2021
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
6.6L V8 Biodiesel
Exterior colour:
White
Fuel type:
Biodiesel
Transmission:
Automatic
Mileage:
125,000
Stock #:
S17625
VIN:
1GT49REYXMF197675
Vehicle photo unavailable

 

2021 GMC Sierra 2500HD

Denali Crew Cab 4WD

125,000 km

Dartmouth, NS
Good Deal
Certified Pre-Owned

$64,977

Year:
2022
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
6.6L V8 Biodiesel
Exterior colour:
Black
Fuel type:
Biodiesel
Interior colour:
Black
Transmission:
Automatic
Mileage:
126,371
Stock #:
260280A
VIN:
1GT49REY4NF159697
Vehicle photo unavailable
New arrival

 

2022 GMC Sierra 2500HD

Denali Crew Cab 4WD

126,371 km

Ottawa, ON
Good Deal

$64,000

Year:
2022
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
6.6L V8 Biodiesel
Exterior colour:
Silver
Fuel type:
Biodiesel
Interior colour:
Black
Transmission:
Automatic
Mileage:
55,983
Stock #:
Q170A
VIN:
1GT49REY4NF292802
Silver 2022 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic
New arrival

 

2022 GMC Sierra 2500HD

Denali Crew Cab 4WD

55,983 km

Prince Albert, SK
Good Deal
Certified Pre-Owned

$73,998

Year:
2021
Make:
GMC
Model:
Sierra 2500HD
Body type:
Pickup Truck
Doors:
4 doors
Drivetrain:
Four-Wheel Drive
Engine:
401 hp 6.6L V8
Exterior colour:
White
Fuel type:
Gasoline
Interior colour:
Black
Transmission:
Automatic
Mileage:
62,726
Stock #:
160372TA
VIN:
1GT49NE76MF291570
White 2021 GMC Sierra 2500HD Pickup Truck Four-Wheel Drive Automatic
New arrival

 

2021 GMC Sierra 2500HD

SLT Crew Cab 4WD

62,726 km

Fort Saskatchewan, AB
Good Deal

$67,909

CarGurus Analysis: 2021 GMC Sierra 2500HD

Image Not Available

Summary

  • With 90 currently listed for sale and an average price of $58,243 CAD, 33.3% of 2021 GMC Sierras 2500HD for sale on CarGurus are rated as good or great deals.

  • Favourably reviewed: Owners rated the 2021 GMC Sierra 2500HD 5 / 5 stars.

  • 100.0% of 2021 Sierra 2500HD models on CarGurus are accident free.

Why it stands out

The 2021 GMC Sierra 2500HD stands out as a heavy-duty pickup that leans more upscale than many rivals. In this generation, GMC offers more trim levels and a wider range of upscale options and features than the related Chevy Silverado 2500HD, and the Denali and Denali Ultimate trims are positioned as the most luxurious choices. For buyers who want a work truck that can still feel well equipped, that broader spread of comfort and premium content is a major part of its appeal.

The 2021 model also benefits from a strong mix of technology and capability. It comes with a 6.6-litre V8 gas engine paired with a six-speed automatic transmission, and it is also available with a 6.6-litre Duramax turbodiesel V8 engine and a 10-speed automatic transmission from Allison. Rear- and four-wheel drive are available, and the cabin can be had in Regular Cab, Crew Cab, or Double Cab form with 7' or 8'2" cargo bed options. Features such as Bluetooth, Android Auto, Apple CarPlay, and Wi-Fi hotspot accessibility help it feel more modern than many heavy-duty trucks, while available touches like remote keyless entry, rear-seat reminders, a Bose premium audio system, power-adjustable front seats, chrome grille trim, dual-zone automatic climate control, and power-folding tailgate options add to its everyday usability.

There are trade-offs, though. The 2021 GMC Sierra 2500HD is described as having numerous problems, including check engine lights tied to diesel particulate filters or emissions sensors, sluggish infotainment responses, rough or delayed shifts, electrical glitches, MultiPro tailgate flaws, and faulty trailer brake controllers. It is also noted that these trucks had very high MSRPs when new, so the used market can still reflect that premium positioning.

Other model years to consider

  • 2024 GMC Sierra 2500HD

    • Average price: $78,758 CAD
    • Good/great deal percentage: 31.7%
    • User rating: 4.2 / 5
    • Total listings: 186
  • 2025 GMC Sierra 2500HD

    • Average price: $92,770 CAD
    • Good/great deal percentage: 33.8%
    • User rating: 5 / 5
    • Total listings: 154
  • 2020 GMC Sierra 2500HD

    • Average price: $56,496 CAD
    • Good/great deal percentage: 40.4%
    • User rating: 4.86 / 5
    • Total listings: 57

This analysis is based on CarGurus' proprietary market data from September 7, 2026, CarGurus experts' opinions, and generative AI.

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