2021 Lexus IS vs 2022 Mercedes-Benz S-Class

2021 Lexus IS
2021 Lexus IS
$39,050MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now
2021 Lexus IS
$39,050MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now

Overview

MSRP

$39,050

MSRP

$111,100

Listings

23

Listings

23

Ratings & Reviews

User Reviews
User Reviews

Expert reviews

7.3 out of 10

Expert reviews

8.7 out of 10

2021 Lexus IS Reviews Summary

The new Lexus IS enters its fourth generation of production, embodying lessons learned from the LC and RC. The 2021 IS targets enthusiast drivers and luxury buyers who might be thinking German first, and it seeks to recalibrate expectations of what a compact luxury sports sedan can be.

2022 Mercedes-Benz S-Class Reviews Summary

The 2022 Mercedes-Benz S-Class is a full-size four-door luxury sedan with a 48-volt mild hybrid system as part of its gasoline-electric powertrain, including a turbocharged 3.0-litre inline-6-cylinder gas engine (S500) or twin-turbo 4.0-litre V8 (S580), with EQ Boost, a nine-speed automatic transmission, and all-wheel drive (AWD). The S500 starts at $123,500; the S580 starts at $139,900. Natural Resources Canada estimates the S500 can achieve fuel consumption as low as 11.4 litres per 100 kilometres city/8.0 highway/9.9 combined, while the S580 is rated at 14.3 L/100 km city/9.5 highway/12.2 combined.
No video found

Popular Features & Specs

Engine

2.0L 241 hp I4

Engine

3.0L 429 hp I6

Drive Train

RWD

Drive Train

AWD

Seating Capacity

5

Seating Capacity

5

Horsepower

241 hp @ 5800 rpm

Horsepower

429 hp @ 6100 rpm

MPG City

21

MPG City

21

MPG Highway

31

MPG Highway

30
2021 Lexus IS
2021 Lexus IS
$39,050MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now
2021 Lexus IS
$39,050MSRP
Overview
Overview
OverviewShop Now
2022 Mercedes-Benz S-Class
$111,100MSRP
Overview
Overview
OverviewShop Now

Overview

MSRP
$39,050
$111,100
Listings

Ratings & Reviews

User reviews

4.6

4.8

Expert reviews

7.3 out of 10

Read full review

8.7 out of 10

Read full review
Pros & cons
Summary
The new Lexus IS enters its fourth generation of production, embodying lessons learned from the LC and RC. The 2021 IS targets enthusiast drivers and luxury buyers who might be thinking German first, and it seeks to recalibrate expectations of what a compact luxury sports sedan can be.
The 2022 Mercedes-Benz S-Class is a full-size four-door luxury sedan with a 48-volt mild hybrid system as part of its gasoline-electric powertrain, including a turbocharged 3.0-litre inline-6-cylinder gas engine (S500) or twin-turbo 4.0-litre V8 (S580), with EQ Boost, a nine-speed automatic transmission, and all-wheel drive (AWD). The S500 starts at $123,500; the S580 starts at $139,900. Natural Resources Canada estimates the S500 can achieve fuel consumption as low as 11.4 litres per 100 kilometres city/8.0 highway/9.9 combined, while the S580 is rated at 14.3 L/100 km city/9.5 highway/12.2 combined.
Video
No video found

Popular Features & Specs

Engine
2.0L 241 hp I4
3.0L 429 hp I6
Drive Train
RWD
AWD
Seating Capacity
5
5
Horsepower
241 hp @ 5800 rpm
429 hp @ 6100 rpm
MPG City
21
21
MPG Highway
31
30
Look and feel

2021 Lexus IS

8/10

2022 Mercedes-Benz S-Class

9/10

The 2021 Lexus IS was a testament to the idea that a car could reflect its owner's personality. With its athletic proportions and dynamic stance, the IS made a bold statement even when stationary. Its design captured a sense of motion, with an elegant distance between the front axle and dashboard, and a fast roofline that balanced between a coupe-like dome and a fastback. The distinctive kick-up of the window base at the rear added a sporty touch, while the spindle grille and narrow headlights gave it an assertive look. Inside, the IS featured a simple yet modern dashboard, with a retro hi-fi feel to the centre stack. The interior's bold lines and high build quality matched the exterior's modern aesthetic, although the analog clock felt outdated amidst the contemporary design.

In contrast, the 2022 Mercedes-Benz S-Class continued to impress with its sleek and sophisticated design, following a complete makeover in the previous year. The S-Class maintained its status as a flagship sedan, with a lineage dating back to the 1954 "Ponton" models. The seventh-generation S-Class, known as the W223, was a testament to Mercedes-Benz's commitment to luxury and elegance. Its extended, low profile exuded sophistication, with a long distance between the front axle and dashboard enhancing its elegant appearance. The S-Class's exterior was defined by its sleek lines and proud Mercedes-Benz grille, while the interior boasted a waterfall of open-pore wood trim and a 12.8-inch touchscreen in the centre stack. The cabin was adorned with high-quality materials, meticulously fitted and assembled, providing a luxurious and comfortable environment for both driver and passengers.

Picture of 2021 Lexus IS
Picture of 2021 Lexus IS
Picture of 2021 Lexus IS
Picture of 2021 Lexus IS
Picture of 2021 Lexus IS
Picture of 2021 Lexus IS
Picture of 2021 Lexus IS
Picture of 2021 Lexus IS
Picture of 2021 Lexus IS
Performance

2021 Lexus IS

7/10

2022 Mercedes-Benz S-Class

8/10

The 2021 Lexus IS was designed to compete in the luxury sports sedan category, with a focus on delivering a sporty driving experience. It featured the "Lexus Driving Signature," a philosophy aimed at providing linear operation and seamless transitions during cornering. The IS 300 RWD was equipped with a 2.0-litre turbocharged inline four-cylinder engine producing 241 horsepower and 258 pound-feet of torque, while the AWD version had a 3.5-litre V6 engine with 260 hp and 236 lb-ft of torque. The IS 350, available only with AWD in Canada, offered 311 hp and 280 lb-ft of torque. The IS's top speed was 230 km/h, with acceleration from 0-60 mph ranging from 6.9 seconds for the IS 300 RWD to 5.6 seconds for the IS 350 RWD. Fuel efficiency varied, with the IS 300 RWD achieving 11.0 L/100 km in the city and 7.6 on the highway, while the AWD version had slightly higher consumption.

The 2022 Mercedes-Benz S-Class, on the other hand, offered a blend of power and luxury, making it suitable for both commuting and pleasure driving. The S500 model featured a turbocharged 3.0-litre inline-six-cylinder engine with EQ Boost, providing 429 hp and 384 lb-ft of torque, with an additional 21 hp and 184 lb-ft from the electric motor. The S580 model had a twin-turbocharged 4.0-litre V8 engine, also benefiting from EQ Boost. Both models used a nine-speed automatic transmission with standard 4Matic AWD. Despite their weight, the S500 and S580 were quick, with 0-100 km/h times of 4.9 and 4.4 seconds, respectively. The S-Class offered a smooth and responsive driving experience, with fuel consumption rated at 11.4 L/100 km city/8.0 highway for the S500 and 14.3 L/100 km city/9.5 highway for the S580.

Form and function

2021 Lexus IS

7/10

2022 Mercedes-Benz S-Class

9/10

The 2021 Lexus IS prioritized driver-centred design, with an adjustable driver position and comfortable, supportive seats. The F Sport trim's bolstered seat was standard in IS 350 models, offering heating and ventilation. The IS featured NuLuxe synthetic upholstery, which was eco-friendly and easy to clean. Storage space was ample, with various compartments and a 305.8-litre trunk. The rear seats were comfortable for two passengers, though legroom was limited.

The 2022 Mercedes-Benz S-Class excelled in providing a luxurious and spacious cabin. Second-row passengers enjoyed powered sun blinds and a Panorama Sunroof, while the 510-litre trunk offered ample storage. The cabin featured six USB-C ports and a 115-volt power supply. The driver and front passenger benefited from rapid-heating active multicontour seats, with options for ventilated seats, heated armrests, and massaging rear seats. The Executive Rear Seating package in the S580 catered to chauffeured passengers, offering a 43-degree recline and additional controls. The S-Class's doors opened wide, but soft-close functionality prevented slamming.

Technology

2021 Lexus IS

7/10

2022 Mercedes-Benz S-Class

9/10

The 2021 Lexus IS introduced a touchscreen infotainment system with Android Auto and Apple CarPlay, alongside Lexus's connected services. The system included a three-year trial of Lexus Enform Safety Connect and an eight-year subscription to Lexus Enform Service Connect. The Mark Levinson 17-speaker audio system was a standout feature, offering high-quality sound.

The 2022 Mercedes-Benz S-Class was equipped with cutting-edge technology, including a 12.8-inch OLED touchscreen and the latest MBUX infotainment system. The OLED screen offered superior image quality and energy efficiency, while the 12.3-inch LED virtual instrument panel provided customizable themes. The S-Class featured augmented video for navigation and an optional augmented reality head-up display. The Burmester 3D Surround sound system delivered high-fidelity audio, with an available 4D system for an immersive experience. The S-Class also boasted EQ Boost and rear-axle steering for enhanced performance.

Safety

2021 Lexus IS

7/10

2022 Mercedes-Benz S-Class

9/10

The 2021 Lexus IS received top safety ratings, with a Top Safety Pick+ from the IIHS and a five-star rating from the NHTSA. It came with Lexus Safety System+ 2.5, offering a range of safety features, including a pre-collision system, lane-departure warning, and adaptive cruise control. The IS also featured blind-spot monitoring, a backup camera, and LED lighting.

The 2022 Mercedes-Benz S-Class was equipped with advanced safety and driver assistance systems, including Magic Vision Control, active distance assist, and active brake assist. The S-Class also featured Pre-Safe systems, car-to-x communication, and available rear-passenger airbags. These features ensured a high level of safety for both driver and passengers.

Cost Effectiveness

2021 Lexus IS

undefined/10

2022 Mercedes-Benz S-Class

undefined/10
N/A

CarGurus highlights

Winning Vehicle Image

According to CarGurus experts, the overall rating for the 2021 Lexus IS was 7.3 out of 10, while the 2022 Mercedes-Benz S-Class scored 8.7 out of 10. Based on these ratings, the 2022 Mercedes-Benz S-Class is the recommended choice for those seeking a luxurious and technologically advanced sedan with superior performance and safety features.

CarGurus highlights

Winning Vehicle Image

According to CarGurus experts, the overall rating for the 2021 Lexus IS was 7.3 out of 10, while the 2022 Mercedes-Benz S-Class scored 8.7 out of 10. Based on these ratings, the 2022 Mercedes-Benz S-Class is the recommended choice for those seeking a luxurious and technologically advanced sedan with superior performance and safety features.

CarGurus logo

By: CarGurus + AI

At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.

Popular vehicle comparisons

2023 Mercedes-Benz S-Class vs 2023 Honda Civic Hatchback2023 Hyundai Elantra vs 2023 Mercedes-Benz S-Class2023 Subaru Impreza vs 2024 Mercedes-Benz S-Class2023 Mercedes-Benz E-Class vs 2023 Mercedes-Benz S-Class2023 Hyundai Sonata vs 2024 Mercedes-Benz S-Class2023 Mercedes-Benz S-Class vs 2023 Volkswagen Golf GTI2023 Mercedes-Benz S-Class vs 2023 Toyota Prius2023 Honda Civic vs 2024 Mercedes-Benz S-Class2023 Honda Civic Hatchback vs 2024 Mercedes-Benz S-Class2023 Mercedes-Benz S-Class vs 2023 Subaru Impreza2023 MINI Cooper vs 2024 Mercedes-Benz S-Class2023 Toyota Prius vs 2024 Mercedes-Benz S-Class2023 Mercedes-Benz S-Class vs 2024 Mercedes-Benz S-Class2023 MINI Cooper vs 2023 Mercedes-Benz S-Class2023 Volkswagen Golf GTI vs 2024 Mercedes-Benz S-Class2022 Lexus IS vs 2022 MINI Cooper2022 Toyota Prius vs 2023 Mercedes-Benz S-Class2022 Lexus IS vs 2022 Mercedes-Benz S-Class2022 Mercedes-Benz S-Class vs 2023 Lexus IS2022 Mercedes-Benz E-Class vs 2023 Lexus IS2022 Lexus IS vs 2022 Volkswagen Jetta2022 Volkswagen Jetta vs 2023 Lexus IS2022 Honda Civic Hatchback vs 2023 Mercedes-Benz S-Class2022 Kia K5 vs 2023 Mercedes-Benz S-Class2022 Subaru Impreza vs 2023 Lexus IS2022 Honda Civic Hatchback vs 2023 Lexus IS2022 Volkswagen Golf GTI vs 2023 Mercedes-Benz S-Class2022 Honda Accord vs 2023 Lexus IS2022 BMW 5 Series vs 2023 Mercedes-Benz S-Class2022 Hyundai Sonata vs 2023 Mercedes-Benz S-Class2021 Honda Civic vs 2022 Lexus IS2021 Honda Civic Hatchback vs 2022 Lexus IS2021 Mercedes-Benz S-Class vs 2022 MINI Cooper2021 Mercedes-Benz S-Class vs 2022 Volkswagen Jetta2021 Chrysler 300 vs 2022 Lexus IS2021 Audi A4 vs 2022 Lexus IS2021 Mercedes-Benz S-Class vs 2022 Honda Accord2021 Hyundai Sonata vs 2022 Lexus IS2021 Mercedes-Benz S-Class vs 2022 Honda Civic2021 Mercedes-Benz S-Class vs 2022 Toyota Prius2021 Mercedes-Benz S-Class vs 2022 Honda Civic Hatchback2021 Mercedes-Benz S-Class vs 2022 Chevrolet Malibu2021 Mercedes-Benz S-Class vs 2022 Mercedes-Benz C-Class2021 Volkswagen Jetta vs 2022 Lexus IS2020 Chrysler 300 vs 2020 Mercedes-Benz S-Class2020 Hyundai Elantra vs 2021 Mercedes-Benz S-Class2020 Volkswagen Jetta vs 2021 Mercedes-Benz S-Class2020 Lexus IS vs 2021 Chevrolet Malibu2020 Mercedes-Benz C-Class vs 2020 Mercedes-Benz S-Class2020 Mercedes-Benz E-Class vs 2021 Mercedes-Benz S-Class2020 Lexus IS vs 2021 Volkswagen Golf GTI2020 Volkswagen Passat vs 2020 Mercedes-Benz S-Class2020 Hyundai Elantra vs 2020 Mercedes-Benz S-Class2020 Lexus IS vs 2021 Hyundai Sonata2020 Lexus IS vs 2021 Volkswagen Jetta2020 MINI Cooper vs 2021 Mercedes-Benz S-Class2020 BMW 5 Series vs 2020 Mercedes-Benz S-Class2020 Lexus IS vs 2021 Audi A42019 Mercedes-Benz E-Class vs 2020 Lexus IS2019 Volkswagen Golf GTI vs 2020 Lexus IS2019 Kia Optima vs 2020 Lexus IS2019 Lexus IS vs 2019 Honda Civic Hatchback2019 Mercedes-Benz C-Class vs 2020 Mercedes-Benz S-Class2019 Chevrolet Impala vs 2019 Lexus IS2019 Subaru Impreza vs 2020 Lexus IS2019 Lexus IS vs 2019 Honda Accord2019 Lexus IS vs 2019 Toyota Prius2019 Hyundai Elantra vs 2019 Lexus IS2019 Volkswagen Jetta vs 2020 Lexus IS2019 Mercedes-Benz E-Class vs 2020 Mercedes-Benz S-Class2019 Honda Accord vs 2020 Lexus IS2019 Chrysler 300 vs 2019 Lexus IS