I have 1988 Honda accord it loses spark wail driving what can it be

You might have a ignition component like a coil that fails when it heats up.

It's gotta be a bad ground...it ALWAYS is a bad ground. start by hosin' off the top of your battery and cable clamps so you don't get airbourne acids in your lungs. next wirebrush both terminals and clean the terminals readying them for 25 amps of juice to be pulled thru without melting anything. next find the other end of the black wire should be connected to both the engine block and jumpered over to the chassis ground with a 1/0 battery cable, all connections free of corrosion so many amps can get comfortably through bolt 'er back up and call it finished...for now-

It still uses ground...like commander data was able to shut down the borg, by pullin' the plug-

i agree with judge roy to check your terminals and cables check your battery too...i also agree with tennisshoes on how difficult it is do diagnos the "losing spark while driving"...you did not mention what happens after it "loses spark" are you able to start the car right away or do you have to wait before you can start it again?

yeah, if it burns up is mysteriously revived...I don't buy it, when somethin' burns up...it's burnt! unless you have a circuit breaker in which case interaction is required to reset the breaker....so seems a little too mysterious, like understanding a "brownout" where power gets thru, like giving whiskey to an alcoholic only a few drops at a time vis-a-vis galvonic currents that are there, you cannot see them or barely can measure them, but they will play hell with solid state electronics, and are a POWERful force, but only move a teenyweenie bit at a time until it gets noticed through failures that you are experiencing today.