Both sliding doors to 2006 Honda Oddysey quite working at the same time?

This is indeed hard to believe. You need to try this method: 1) Turn off the switch of sliding door of the steering wheel, 2) Take out the fuse of sliding door on the passenger side and start the engine; 3) Turn on on the switch and within 10 seconds stop the engine; 4) Turn off the switch again and place back the fuse and start the engine 5) Start the engine and put the switch on and try to open doors. This method will reset your computer. If it works, the issue is not the motor or roller but a bad wire forcing the computer to lock the doors.